Yasuhiro Otomo Selected Research

ART123

1/2021	An Experience of Multiple Hematomas in a Coronavirus Disease-19 Patient Administered with ART-123 and Heparin.
9/2019	Human Soluble Recombinant Thrombomodulin, ART-123, Resolved Early Phase Coagulopathies, but Did Not Significantly Alter the 28 Day Outcome in the Treatment of DIC Associated with Infectious Systemic Inflammatory Response Syndromes.

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Yasuhiro Otomo Research Topics

Disease

26	Sepsis (Septicemia) 11/2023 - 12/2008
24	Wounds and Injuries (Trauma) 05/2023 - 12/2008
16	Disseminated Intravascular Coagulation 03/2023 - 12/2008
14	COVID-19 01/2024 - 01/2020
12	Hemorrhage 01/2023 - 11/2013
8	Out-of-Hospital Cardiac Arrest 03/2024 - 01/2016
8	Infections 10/2023 - 12/2003
8	Multiple Organ Failure (MODS) 01/2022 - 03/2009
7	Septic Shock (Toxic Shock Syndrome) 10/2023 - 11/2019
7	Thrombosis (Thrombus) 01/2023 - 12/2008
7	Pneumonia (Pneumonitis) 01/2022 - 01/2020
5	Inflammation (Inflammations) 02/2024 - 02/2015
5	Heart Arrest (Cardiac Arrest) 10/2023 - 01/2016
5	Shock 01/2022 - 06/2012
4	Ischemia 02/2024 - 12/2020
4	Lymphatic Metastasis 03/2013 - 08/2007
3	Thoracic Injuries (Chest Injury) 07/2023 - 04/2018
3	Reperfusion Injury 01/2023 - 12/2020
3	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2022 - 09/2019
3	Hemorrhagic Shock 10/2021 - 11/2013
3	Acute Lung Injury 01/2020 - 06/2012
3	Hypothermia 01/2019 - 02/2015
3	Neoplasm Metastasis (Metastasis) 03/2013 - 09/2009
2	Esophageal Neoplasms (Esophageal Cancer) 01/2023 - 01/2023
2	Burns 01/2022 - 01/2020
2	Diabetes Mellitus 01/2020 - 08/2011
2	Pneumothorax 01/2020 - 01/2020
2	Pancreatitis 09/2018 - 06/2018
2	Acidosis 09/2016 - 02/2015
2	Breast Neoplasms (Breast Cancer) 03/2013 - 08/2007
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2012 - 09/2009
2	Lung Neoplasms (Lung Cancer) 12/2012 - 09/2009
2	Neoplasms (Cancer) 08/2011 - 09/2009
2	Neoplasm Micrometastasis 08/2007 - 01/2006
2	Dehydration (Water Stress) 04/2004 - 12/2003
1	Ulcerative Colitis 02/2024
1	Mesenteric Ischemia 02/2024
1	Thrombocytopenia (Thrombopenia) 11/2023
1	Surgical Wound Infection 05/2023
1	Hypoxia (Hypoxemia) 01/2023
1	Ulcer 01/2023

Drug/Important Bio-Agent (IBA)

15	Dacarbazine (DIC)FDA LinkGeneric 03/2023 - 12/2008
7	AnticoagulantsIBA 11/2023 - 11/2019
6	LipidsIBA 12/2023 - 06/2012
6	Messenger RNA (mRNA)IBA 03/2013 - 01/2006
5	Nucleic AcidsIBA 03/2013 - 01/2006
4	Biomarkers (Surrogate Marker)IBA 02/2024 - 09/2019
4	FibrinIBA 08/2022 - 02/2015
4	Thrombin FDA Link 01/2022 - 02/2015
4	AntithrombinsIBA 01/2022 - 12/2013
4	Anti-Bacterial Agents (Antibiotics)IBA 03/2020 - 09/2018
3	salicylhydroxamic acid (SHAM)IBA 02/2024 - 06/2012
3	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2023 - 06/2012
3	Heparin (Liquaemin)FDA LinkGeneric 01/2022 - 01/2021
3	Fibrinogen (Factor I)FDA Link 01/2020 - 09/2016
2	Lactic Acid (Lactate)FDA LinkGeneric 02/2024 - 11/2021
2	A-factor (Streptomyces)IBA 03/2023 - 09/2022
2	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 01/2023 - 12/2020
2	Proteins (Proteins, Gene)FDA Link 01/2023 - 04/2004
2	estropipate (Ogen)FDA LinkGeneric 08/2022 - 02/2015
2	fibrin fragment D (D-dimer)IBA 06/2021 - 01/2021
2	Indicators and Reagents (Reagents)IBA 01/2021 - 09/2016
2	ART123IBA 01/2021 - 09/2019
2	MetalsIBA 01/2018 - 12/2003
2	Keratin-19 (Keratin 19)IBA 12/2012 - 08/2007
2	Hormones (Hormone)IBA 04/2004 - 12/2003
1	11 alpha- hydroxy- 9,15- dioxo- 2,3,4,5,20- pentanor- 19- carboxyprostanoic acidIBA 02/2024
1	Dinoprostone (PGE2)FDA Link 02/2024
1	ProstaglandinsIBA 02/2024
1	tetraethylpyrazine (TEP)IBA 11/2023
1	Intravenous Immunoglobulins (IVIG)FDA Link 10/2023
1	Immunoglobulin G (IgG)IBA 01/2023
1	Immunoglobulin A (IgA)IBA 01/2023
1	Cardiolipins (Cardiolipin)IBA 01/2023
1	Immunoglobulin M (IgM)IBA 01/2023
1	LeptinIBA 01/2023
1	Viral ProteinsIBA 01/2023
1	Prothrombin (Factor II)IBA 01/2023
1	Antiphospholipid AntibodiesIBA 01/2023
1	Glycoproteins (Glycoprotein)IBA 01/2023
1	PhosphatidylserinesIBA 01/2023

Therapy/Procedure

18	Therapeutics 11/2023 - 12/2012
11	Resuscitation 07/2023 - 01/2013
10	Cardiopulmonary Resuscitation (CPR) 03/2024 - 07/2017
8	Laparotomy 05/2023 - 06/2012
8	Critical Care (Surgical Intensive Care) 01/2022 - 04/2009
6	Artificial Respiration (Mechanical Ventilation) 01/2024 - 01/2020
5	Extracorporeal Membrane Oxygenation 08/2023 - 01/2020
4	Mechanical Ventilators (Ventilator) 11/2021 - 01/2018
3	Sutures (Suture) 05/2023 - 01/2020
3	Length of Stay 01/2022 - 01/2021
3	Vagus Nerve Stimulation 10/2021 - 01/2020
2	Airway Management 09/2023 - 01/2023
2	Patient Care Bundles 01/2022 - 11/2019
2	Operative Surgical Procedures 01/2020 - 11/2013
2	Thoracotomy 01/2020 - 02/2017
1	Intra-Aortic Balloon Pumping 08/2023
1	Negative-Pressure Wound Therapy 05/2023
1	Lymph Node Excision (Lymph Node Dissection) 01/2023
1	Esophagectomy 01/2023